Reynolds: A Guide to Sample Size for Animal-based Studies
A Guide to Sample Size for Animal-based Studies
Buch
- Wiley, 09/2023
- Einband: Kartoniert / Broschiert, Paperback
- Sprache: Englisch
- ISBN-13: 9781119799979
- Bestellnummer: 11095986
- Umfang: 288 Seiten
- Gewicht: 736 g
- Maße: 280 x 216 mm
- Stärke: 16 mm
- Erscheinungstermin: 12.9.2023
Achtung: Artikel ist nicht in deutscher Sprache!
Klappentext
A Guide to Sample Size for Animal-based StudiesUnderstand a foundational area of experimental design with this innovative reference
Animal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs - Replacement, Reduction and Refinement - the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.
A Guide to Sample Size for Animal-based Studies meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to "rightsizing" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results.
This book offers:
* Step-by-step guidance in diverse methods for approximating and refining sample size
* Detailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies
* Sample size approximation methods for different types of data - binary, continuous, ordinal, time to event - and different study types - description, comparison, nested designs, reference interval construction and dose-response studies
* Numerous worked examples, using real data from published papers, together with SAS and R code
A Guide to Sample Size for Animal-based Studies is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.