Natural Killer Cells, Gebunden

Klappentext

This revised second edition highlights the growing importance of natural killer (NK) cells as key contributors to immune defense and immune regulation. Their unique position between innate and adaptive immunity has made them central to current research, from understanding infection and inflammation to designing nextgeneration immunotherapies.

Across six parts, the book integrates fundamental NKcell biology with insights from disease settings and advanced experimental approaches. It shows how developmental pathways, receptor systems and repertoire diversity shape NKcell function, and how these cells respond and adapt in the context of viral infection, chronic inflammation and cancer. This includes emerging evidence on their roles in SARSCoV2, fungal immunity and vascular and autoimmune disorders.

The volume also reveals how NKcell behavior differs across tissues such as the eye, lung, liver, uterus and skin, reflecting the influence of distinct microenvironments. Further chapters trace how cytokine signaling, immunometabolism and extracellular vesicles finetune NKcell activity.

A dedicated section on immunotherapy presents rapidly advancing strategies---from engineered NKcell lines to CARNK and iPSCderived approaches---while the final part introduces cuttingedge investigative methods, including organoid models, epigenetic analysis and AIenabled concepts for therapy design.

With its coherent structure and forwardlooking scope, this reference work supports researchers and clinicians seeking to understand how NK cells are shaping modern immunology.